How Tobacco Smoke Causes Disease: The Biology and Behavioral Basis for Smoking-Attributable Disease, A Report of the Surgeon General

How Tobacco Smoke Causes Disease: The Biology and Behavioral Basis for Smoking-Attributable Disease, A Report of the Surgeon General
Title:
How Tobacco Smoke Causes Disease: The Biology and Behavioral Basis for Smoking-Attributable Disease, A Report of the Surgeon General
Format:
Paperback
USA Price: 
$66.00
$16.50
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Stock:
In stock
GPO Stock Number:
017-023-00219-8
ISBN:
9780160840784
Description

Edited by David Sidransky, et al. Explains beyond a shadow of a doubt how tobacco smoke causes disease, validates earlier findings, and expands and strengthens the science base. Describes in detail the ways tobacco smoke damages every organ in the body and causes disease and death. Substantiates the evidence that there is no safe level of exposure to cigarette smoke.

In 1964, the Surgeon General released a landmark report on the dangers of smoking. During the intervening 45 years, 29 Surgeon General’s reports have documented the overwhelming and conclusive biologic, epidemiologic, behavioral, and pharmacologic evidence that tobacco use is deadly. Our newest report, How Tobacco Smoke Causes Disease, is a comprehensive, scientific discussion of how mainstream and secondhand smoke exposures damage the human body. Decades of research have enabled scientists to identify the specific mechanisms of smoking-related diseases and to characterize them in great detail. Those biologic processes of cigarette smoke and disease are the focus of this report.

NOTE: NO FURTHER DISCOUNTS FOR ALREADY REDUCED SALE ITEMS.

Table of Contents

Table of Contents:

Message from Kathleen Sebelius

Foreword

Preface

Acknowledgments

1. Introduction, Evaluation of Evidence on Mechanisms of Disease Production, and Summary

Introduction

Major Conclusions

Chapter Conclusions

References

2. The Changing Cigarette

Introduction

Cigarette Design Changes over the Years

New Cigarette Products

Low-Nicotine Cigarettes

Cigarette-Like Products

Evaluation of New Cigarette Products

New Oversight of Tobacco Products

Summary

Conclusions

References

3. Chemistry and Toxicology of Cigarette Smoke and Biomarkers of Exposure and Harm

Introduction

Chemistry

Biomarkers

Summary

Conclusions

References

4. Nicotine Addiction: Past and Present

Introduction

Definition of Nicotine Addiction

Tobacco Constituents and Pharmacokinetics

Components of Nicotine Addiction

Pathophysiology of Nicotine Addiction

Genetics

Prevalence and Trajectory Toward Nicotine Dependence

Epidemiology of Tobacco Use and Nicotine Dependence in Adults

Trajectory of Recovery or Relapse

Evidence Summary

Conclusions

References

5. Cancer

Introduction

Carcinogen Exposure, Metabolism, and DNA Adducts

DNA Repair and Conversion of Adducts to Mutations

Gene Mutations in Tobacco-Induced Cancer

Loss of Mechanisms for Growth Control

Other Aspects

Evidence Summary

Conclusions

References

6. Cardiovascular Diseases

Introduction

Tobacco Use and Cardiovascular Disease

Secondhand Tobacco Smoke and Cardiovascular Disease

Pathophysiology

Hemodynamic Effects

Smoking and the Endothelium

Thrombogenic Effects

Inflammation

Smoking and Diabetes

Lipid Abnormalities

Cardiovascular Biomarkers

Smoking Cessation and Cardiovascular Disease

Methods to Reduce Exposure

Evidence Summary

Conclusions

References

7. Pulmonary Diseases

Introduction

Smoking and Respiratory Defense Mechanisms

Oxidative Stress

Oxidative Stress in Chronic Obstructive Pulmonary Disease

Genetics of Pulmonary Disease and Susceptibility to Tobacco Smoke

Pathogenesis of Emphysema

Summary

Evidence Summary

Conclusions

Implications

References

8. Reproductive and Developmental Effects

Introduction

Review of Epidemiologic Literature on Smoking

Pathophysiological and Cellular and Molecular Mechanisms of Smoking

Implications

Evidence Summary

Conclusions

References

9. A Vision for the Future

The Global Tobacco Epidemic

Reducing the Risks from Smoking

Ending the Tobacco Epidemic

Concluding Remarks

Appendix 9.1 Recommendations for Future Research

Appendix 9.2 Ending the Tobacco Problem: A Blueprint for the Nation

Appendix 9.3 Promoting Healthy Lifestyles: Policy, Program, and Personal Recommendations for Reducing Cancer Risk

References

List of Abbreviations

Definitions and Alternative Nomenclature of Genetic Symbols Used in This Report

Audience

Physicians, medical researchers, and smokers would all find the medical studies evaluating the dangerous effects of cigarettes useful.  In addition, community groups, youth groups, and other groups interested in preventing smoking in youth and adults (and/or helping youth and adults quit smoking) would find these facts very useful.

Product Details

Availability Details:
In Stock
USA Price:
$16.50
International Price:
$23.10
Publisher:
Health and Human Services Dept., Public Health Service, Office of the Surgeon Genral
Author:
  • Sidransky, David.
Key Phrases:
  • Biology and Behavioral Basis for Smoking-Attributable Disease
  • Report of the Surgeon General
  • Tobacco, adverse effects, United States, Statistics
  • Smoking, adverse effects, United States, Statistics
  • Tobacco Use Disorder
  • Tobacco Smoke Pollution
Weight:
3.9375
Quantity Price:
Discount
Cover:
Paper
Unit of Issue (US):
1
Unit of Issue (Non-US):
1
Record Creation Date:
12/09/2010
Last Status Update:
05/06/2019
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